The global obesity epidemic that was previously reported [1,2] is now to worsen with obesity to double in 73 countries around the world [3,4]. Improving the health of obese individuals by dietary restriction, anti-obese foods and increased physical activity [1] has not reduced the global obesity epidemic. Obesity is linked to nonalcoholic fatty liver disease (NAFLD) [5,6] with complications relevant to the metabolic syndrome and cardiovascular disease [7]. Appetite control has become critical to endocrinology and metabolism with the apelinergic pathway and nuclear receptor Sirtuin 1 (Sirt 1) now connected to the endocrine system [8] and critical to metabolism. The apelin-Sirt 1 interaction involves nitric oxide (NO) [9] that is now considered as the defect [10] in the interaction between the peptide apelin and calorie sensitive gene Sirt 1 involved in NO imbalances in the adipose tissue, liver and the brain.
Appetite dysregulation and obesity inWestern Countries. LAP LAMBERT Academic Publishing. 2013. Ref.: https://goo.gl/9Q9tnW
Martins IJ. Induction ofNAFLD with Increased Risk of Obesity and Chronic Diseases in DevelopedCountries. OJEM Diseases. 2014; 4: 90-110. Ref.: https://goo.gl/uHz7H6
An R, Ji M, Zhang S. Global warming and obesity: a systematicreview. Obes Rev. 2018; 19: 150-163. Ref.: https://goo.gl/i9GpEv
Friedrich MJ. Global Obesity Epidemic Worsening. JAMA.2017; 318:603. Ref.: https://goo.gl/79iEGw
Fabbrini E, Sullivan S,Klein S. Obesity and non-alcoholicfatty liver disease: biochemical, metabolic, and clinical implications. Hepatology.2010; 51: 679-689. Ref.: https://goo.gl/ebJjFZ
DietrichP, Hellerbrand C. Non-alcoholic fatty liver disease, obesity and themetabolic syndrome. Best Pract Res Clin Gastroenterol. 2014; 28: 637-653.Ref.: https://goo.gl/ecCzVn
Kim SH, Després JP, Koh KK. Obesity and cardiovascular disease:friend or foe? Eur Heart J. 2016; 37: 3560-3568. Ref.: https://goo.gl/4ZjohT
Martins IJ. Nutritionaldiets accelerate amyloid beta metabolism and prevent the induction ofchronic diseases and Alzheimer’s disease. J Endocrinol andMetab. Photon. 2015; 1-48.
Apelinergic System Defects with Relevance to Mental Disorders inDiabetes. World J Psychiatry Ment Health Res. 2017; 1: 1001. Ref.: https://goo.gl/q3yoRr
Martins IJ. UnhealthyNutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. JMol Genet Med. 2015; 9: 1-8. Ref.: https://goo.gl/mWnRMX
QureshiK, Abrams GA. Metabolic liver disease of obesity and role of adiposetissue in the pathogenesis of nonalcoholic fatty liver disease. World JGastroenterol. 2007; 13: 3540-3553. Ref.: https://goo.gl/56N5AG
Martins IJ. Avasimibe andSirt 1 Activators Reverse NAFLD and Obesity. Nov Appro Drug Des Dev. 2017;1: 1-2.
Mechanisms underlying current and future anti-obesity drugs. TrendsNeurosci. 2013; 36: 133-40. Ref.: https://goo.gl/1n2Ha4
García-RuizC, Baulies A, Mari M, García-Rovés PM, Fernandez-Checa JC. Mitochondrialdysfunction in non-alcoholic fatty liver disease and insulin resistance:cause or consequence?Free Radic Res. 2013; 47: 854-868.Ref.: https://goo.gl/iwfFy7
Martins IJ. Defective Interplaybetween Adipose Tissue and Immune System Induces Non Alcoholic Fatty LiverDisease. Updates Nutr Disorders Ther. 2017; 1: 3.1. Ref.: https://goo.gl/YQSnyd
Martins IJ. Autoimmunedisease and mitochondrial dysfunction in chronic diseases.Res Chron Dis.2017; 1: 10-12. Ref.: https://goo.gl/LXak5D
MazzucotelliA, Ribet C, Castan-Laurell I, Daviaud D, Guigné C, et al. Thetranscriptional co-activator PGC-1alpha up regulates apelin in human andmouse adipocytes. Regul Pept. 2008; 150: 33-37. Ref.: https://goo.gl/rJtdLa
KilicU, Gok O, Bacaksiz A, Izmirli M, Elibol-Can B, et al. SIRT1gene polymorphisms affect the protein expression in cardiovasculardiseases. PLoS One. 2014; 9: 90428. Ref.: https://goo.gl/3Y8B9Y
Biason-Lauber A, Böni-Schnetzler M, HubbardBP, Bouzakri K, Brunner A, etal. Identification of a SIRT1Mutation in a Family with Type 1 Diabetes. Cell Metab. 2013; 17: 448-455.Ref.: https://goo.gl/xjz2Qm
Hughes JW, Herold KC. Novel SIRT1 MutationLinked to Autoimmune Diabetes in Humans. Cell Metab. 2013; 17: 311-312. Ref.: https://goo.gl/NQ5rtv
Type 3 diabetes with links to NAFLD and Other Chronic Diseases in theWestern World. Int J Diab and Metab Disord. 2016; 1: 1-5. Ref.: https://goo.gl/hGqXFe
Martins IJ. Heat shock gene Sirtuin 1 regulatespost-prandial lipid metabolism with relevance to nutrition and appetiteregulation in diabetes. Int J Diab Clin Diagn. 2016; 3: 1-3. Ref.: https://goo.gl/WdzCgC
Martins IJ. Regulation ofCore Body Temperature and the Immune System Determines Species Longevity.Curr Updates Gerontol. 2017; 1: 6. Ref.: https://goo.gl/y3tCqE
Martins IJ. CaffeineConsumption and Induction of Obesity in the Developed World. Ann ObesDisord. 2017; 2: 1018. https://goo.gl/km1Unh
Martins IJ. NutritionTherapy Regulates Caffeine Metabolism with Relevance to NAFLD andInduction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019. Ref.: https://goo.gl/ukJA55
Caffeine with Links to NAFLDand Accelerated Brain Aging. In Tech Open. 2017. Ref.: https://goo.gl/8dZsGD
Martins IJ. Caffeineconsumption with Relevance to Type 3 diabetes and accelerated brain aging.Res Reveiws: Neurosci. 2016; 1: 1-5. Ref.: https://goo.gl/qbUzY8
Martins IJ. Indian Spicesand Unhealthy Diets interfere with Drug Therapy in Diabetes andNeurodegenerative Diseases. Nov Appro Drug Des Dev. 2018; 3: 1-4. Ref.: https://goo.gl/H5YZN4
EjazA, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr. 2009; 139:919-925. Ref.: https://goo.gl/XspCuq
TeichT, Pivovarov JA, Porras DP, Dunford EC, Riddell MC. Curcumin limits weightgain, adipose tissue growth, and glucose intolerance following thecessation of exercise and caloric restriction in rats. J Appl Physiol(1985). 2017; 123: 1625-1634. Ref.: https://goo.gl/djjGKY
WangS, Wang X, Ye Z, Xu C, Zhang M, et al. Curcumin promotes browning of whiteadipose tissue in a norepinephrine-dependent way. Biochem Biophys ResCommun. 2015; 466: 247-253. Ref.: https://goo.gl/SuiirT
Curcumin and obesity.Biofactors. 2013; 39: 78-87. Ref.: https://goo.gl/wkqhdv
InzaugaratME, De Matteo E, Baz P, Lucero D, García CC, et al. New evidence for thetherapeutic potential of curcumin to treat nonalcoholic fatty liverdisease in humans. PLoS ONE. 2017; 12: e0172900. Ref.: https://goo.gl/C5CdXU
PanahiY, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, et al. Efficacyand Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: ARandomized Controlled Trial. Drug Res (Stuttg). 2017; 67: 244-251. Ref.: https://goo.gl/QzbkiS
RahmaniS, Asgary S, Askari G, Keshvari M, Hatamipour M, et al.Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A RandomizedPlacebo-controlled Trial. Phytother Res. 2016; 30: 1540-1548. Ref.: https://goo.gl/oBQ7j7
BaligaMS, Jagetia GC, Rao SK, Babu K. Evaluation of nitric oxide scavengingactivity of certain spices in vitro: a preliminary study. Nahrung. 2003; 47:261-264. Ref.: https://goo.gl/97anfL
KalaivaniP, Saranya RB, Ramakrishnan G, Ranju V, Sathiya S, et al. Cuminum cyminum,a dietary spice, attenuates hypertension via endothelial nitric oxidesynthase and NO pathway in renovascular hypertensive rats. Clin ExpHypertens. 2013; 35: 534-542. Ref.: https://goo.gl/R5V2P9
Nakatake R, Hishikawa H,Matsuhima H, Nakamura Y, Ishizaki M, et al. Curcumin protects liverinflammation by suppressing expression of inducible nitric oxide synthasein primary cultured rat hepatocytes. Functional Foods in Health andDisease. 2017; 7: 716-734. Ref.: https://goo.gl/CyxUaA
CalabreseV, Scapagnini G, Colombrita C, Ravagna A, Pennisi G, et al. Redoxregulation of heat shock protein expression in aging and neurodegenerativedisorders associated with oxidative stress: a nutritional approach. AminoAcids. 2003; 25: 437-444. Ref.: https://goo.gl/kZ3LvS
MaitP, Manna J. Activation of Heat Shock Proteins by Nanocurcumin to PreventNeurodegenerative Diseases. Brain Disord Ther. 2014; 3:139. Ref.: https://goo.gl/vSsgkU
ShatwanIA, Ahmed LA, Badkook MM. Effect of barley flour, crude cinnamon, andtheir combination on glycemia, dyslipidemia, and adipose tissue hormonesin type 2 diabetic rats. J Med Food. 2013; 16: 656-662. Ref.: https://goo.gl/uvZt6j
LopesBP, Gaique TG, Souza LL, Paula GS, Kluck GE, et al. Cinnamon extractimproves the body composition and attenuates lipogenic processes in theliver and adipose tissue of rats. Food Funct. 2015; 6: 3257-3265. Ref.: https://goo.gl/5bCMBm
Kwan HY, Wu J, Su T, ChaoX-C, Liu B, et al. Cinnamon induces browning in subcutaneous adipocytes.Scientific Reports. 2017; 7: 2447. Ref.: https://goo.gl/NGzgYy
AskariF, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits onlipid profile, liver enzymes, insulin resistance, and high-sensitivityC-reactive protein in nonalcoholic fatty liver disease patients. Nutr Res.2014; 34: 143-148. Ref.: https://goo.gl/hCkdx7
Hekmatdoost A. Prevention of Nonalcoholic FattyLiver Disease (NAFLD) Progression to Nonalcoholic Steatohepatitis (NASH)by Modification of Lifestyle and Dietary Supplements. J Clin Nutr Diet.2016; 2: 2. Ref.: https://goo.gl/rRi7VN
EslamparastT, Eghtesad S, Poustchi H, Hekmatdoost A. Recent advances in dietarysupplementation, in treating non-alcoholic fatty liver disease. World J Hepatol. 2015; 7:204-212. Ref.: https://goo.gl/C6dmCa
Martins IJ. Insulin TherapyInactivation is connected to NAFLD and Diabetes Severity Index. J DiabClin Stud. 2017; 1: 001-003. Ref.: https://goo.gl/zXAMW3
WilsonPW, Bloom HL. Caffeine Consumption and Cardiovascular Risks: Little Causefor Concern. J Am Heart Assoc. 2016; 5: 003089. Ref.: Ref.: https://goo.gl/mQymj7
DingM, Bhupathiraju SN, Satija A, van Dam RM, Hu FB. Long-term coffeeconsumption and risk of cardiovascular disease: a systematic review and adose-response meta-analysis of prospective cohort studies. Circulation.2014; 129: 643-659. Ref.: https://goo.gl/eY1FgP
Martins IJ. Genomic Medicine and Acute Cardiovascular Disease Progression. Res Chron Dis. 2018.
Ian James Martins*Ian James Martins*. Indian spices and Caffeine treatment for Obesity and Cardiovascular disease. . 2018 doi: 10.29328/journal.acem.1001005; 2: 010-014
Luisetto M*, Ghulam Rasool Mashori and Cabianca lucaLuisetto M*,Ghulam Rasool Mashori,Cabianca luca. New pharmacological strategies in some metabolic endocrine disorder under a toxicological approach. . 2018 doi: 10.29328/journal.acem.1001006; 2: 015-021
Martin Galindo, Katrina M Schrode and Magda Shaheen*Martin Galindo,Katrina M Schrode,Magda Shaheen*. Association between obesity profile and non-alcoholic fatty liver by race/ethnicity. . 2021 doi: 10.29328/journal.acem.1001017; 5: 001-010
Hacer Efnan Melek, Ayça Törel Ergür* and Gökçe Kaan AtaçHacer Efnan Melek,Ayça Törel Ergür*,Gökçe Kaan Ataç. Evaluation of endothelial function in obese children and adolescents. . 2021 doi: 10.29328/journal.acem.1001019; 5: 014-023
Dragan Klaric, Marta Martinis* and Marta KlaricDragan Klaric,Marta Martinis*,Marta Klaric. Metabolic syndrome: A case report. . 2021 doi: 10.29328/journal.acem.1001022; 5: 031-035
Kübra ARSLAN*, Ayça TÖREL ERGÜR and Mehmet Ali YİNANÇKübra ARSLAN*,Ayça TÖREL ERGÜR,Mehmet Ali YİNANÇ. Overlap of two unusual condition in childhood: hibernoma and central diabetes insipidus. . 2022 doi: 10.29328/journal.acem.1001023; 6: 001-003
Sathit Niramitmahapanya*, Preeyapat Chattieng, Tiersidh Nasomphan and Korbtham SathirakulSathit Niramitmahapanya*,Preeyapat Chattieng,Tiersidh Nasomphan,Korbtham Sathirakul. Effects of dietary supplementation on progression to type 2 diabetes in subjects with prediabetes: a single center randomized double-blind placebo-controlled trial. . 2023 doi: 10.29328/journal.acem.1001026; 7: 00-007
Seyed Hamed Mousavi*, Fateme Khorramroo and Hooman MinoonejadSeyed Hamed Mousavi*,Fateme Khorramroo,Hooman Minoonejad. Symmetry of Shank Muscle Strength, Passive Stiffness and Plantar Pressure Following IASTM Accompanied by Electrotherapy in a Case with Severe Ankle Stiffness. J Sports Med Ther. 2024: doi: 10.29328/journal.jsmt.1001089; 9: 091-095
Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024: doi: 10.29328/journal.acr.1001099; 8: 075-077
H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
Denis Tonini, Kai Wu, Renata Saha and Jian-Ping Wang*Denis Tonini,Kai Wu,Renata Saha,Jian-Ping Wang*. Feasibility study of magnetic sensing for detecting single-neuron action potentials. Ann Biomed Sci Eng. 2022 doi: 10.29328/journal.abse.1001018; 6: 019-029
Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024 doi: 10.29328/journal.acr.1001099; 8: 075-077
Khashayar Maroufi*Khashayar Maroufi*. Physical activity can change the physiological and psychological circumstances during COVID-19 pandemic: A narrative review. J Sports Med Ther. 2021 doi: 10.29328/journal.jsmt.1001051; 6: 001-007
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NC A&T State University, USA
Moran Sciamama-Saghiv
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Ekiti State University Teaching Hospital, Nigeria
Ayokunle Dada
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Ido-Ekiti/Afe Babalola University, Nigeria
Dr. Shuaib Kayode Aremu
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Ekiti State University, Nigeria
Adebukola Ajite
I wanna to thank clinical journal of nursing care and practice for its effort to review and publish my manuscript. This is reputable journal. Thank you!
Wollo University, Ethiopia
Atsedemariam Andualem
We appreciate your approach to scholars and will encourage you to collaborate with your organization, which includes interesting and different medical journals.
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Nataliya Kitsera
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Nasrulla Abutaleb
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Department of Biotechnology, Uttaranchal college of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India
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BS, PharmD., MBA, CPHIMS, FHIMSS, Adjunct Professor, Global Healthcare Management, MCPHS University, Chief Strategy Offi cer, MedicaSoft, Senior Advisor, National Health IT (NHIT) Collaborative for Underserved, New York HIMSS, National Liaison, Health 2.0 Boston, Past Chair, Chair Innovation, USA
Helen Figge
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Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA
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Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong
Long Ching
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Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine
Ayman M Abu Mustafa
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Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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