Abstract

Letter to Editor

Myxedema coma in COVID-19

Yuichi Takashi* and Daiji Kawanami*

Published: 31 July, 2021 | Volume 5 - Issue 1 | Pages: 029-030

SARS-CoV-2 infection is associated with thyroid disorders. It has been reported that myxedema coma (MC) can be complicated with COVID-19. COVID-19-related thyroid disorders consist of a broad spectrum of thyroid dysfunction, from thyrotoxicosis to decompensated hypothyroidism. It is possible that both primary and central thyroid disorders are induced by COVID-19 due to systemic inflammatory and immune responses. We experienced two cases in which patients with COVID-19 developed MC with central hypothyroidism. It is likely that MC affected the severity of COVID-19. It is necessary to consider the existence of MC during SARS-CoV-2 infection. We propose the potential mechanisms.

Read Full Article HTML DOI: 10.29328/journal.acem.1001021 Cite this Article Read Full Article PDF

Keywords:

Myxedema; Coma; SARS-CoV-2; COVID-19; Cytokine release syndrome

References

  1. Sinha P, Calfee CS, Cherian S, Brealey D, Cutler S, et al. Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study. Lancet Respir Med. 2020; 8: 1209-1218. PubMed: https://pubmed.ncbi.nlm.nih.gov/32861275/
  2. Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, et al. Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan. J Epidemiol. 2017; 27: 117-22. PubMed: https://pubmed.ncbi.nlm.nih.gov/28142035/
  3. Mathew V, Misgar RA, Ghosh S, Mukhopadhyay P, Roychowdhury P, et al. Myxedema coma: a new look into an old crisis. J Thyroid Res. 2011; 2011: 493462. PubMed: https://pubmed.ncbi.nlm.nih.gov/21941682/
  4. Dixit NM, Truong KP, Rabadia SV, Li D, Srivastava PK, et al. Sudden Cardiac Arrest in a Patient With Myxedema Coma and COVID-19. J Endocr Soc. 2020; 4: bvaa130. PubMed: https://pubmed.ncbi.nlm.nih.gov/32984743/
  5. Caron P. Thyroid disorders and SARS-CoV-2 infection: From pathophysiological mechanism to patient management. Ann Endocrinol (Paris). 2020; 81: 507-510. PubMed: https://pubmed.ncbi.nlm.nih.gov/32950466/
  6. Jara EL, Munoz-Durango N, Llanos C, Fardella C, Gonzalez PA, et al. Modulating the function of the immune system by thyroid hormones and thyrotropin. Immunol Lett. 2017; 184: 76-83. PubMed: https://pubmed.ncbi.nlm.nih.gov/28216261/
  7. Wei L, Sun S, Xu CH, Zhang J, Xu Y, et al. Pathology of the thyroid in severe acute respiratory syndrome. Hum Pathol. 2007; 38: 95-102. PubMed: https://pubmed.ncbi.nlm.nih.gov/16996569/
  8. Pal R. COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications. Endocrine. 2020; 68: 251-252. PubMed: https://pubmed.ncbi.nlm.nih.gov/32346813/

Similar Articles

Recently Viewed

  • Crime Scene Examination of Murder Case
    Subhash Chandra*, Pradeep KR, Jitendra P Kait, SK Gupta and Deepa Verma Subhash Chandra*,Pradeep KR,Jitendra P Kait,SK Gupta,Deepa Verma. Crime Scene Examination of Murder Case. J Forensic Sci Res. 2024: doi: 10.29328/journal.jfsr.1001071; 8: 108-110
  • Beta-1 Receptor (β1) in the Heart Specific Indicate to Stereoselectivity
    Rezk Rezk Ayyad*, Ahmed Mohamed Mansour, Ahmed Mohamed Nejm, Yasser Abdel Allem Hassan, Norhan Hassan Gabr and Ahmed Rezk Ayyad Rezk Rezk Ayyad*, Ahmed Mohamed Mansour, Ahmed Mohamed Nejm, Yasser Abdel Allem Hassan, Norhan Hassan Gabr, Ahmed Rezk Ayyad. Beta-1 Receptor (β1) in the Heart Specific Indicate to Stereoselectivity. Arch Pharm Pharma Sci. 2024: doi: 10.29328/journal.apps.1001060; 8: 082-088
  • Pattern of LRR in Endometrial Cancer and Identification of Predictive Factors
    Alia Mousli, Mohamed Aziz Cherif*, Marouen Benna, Ameni Yousfi, Semia Zaraa, Rim Abidi and Chiraz Nasr Alia Mousli, Mohamed Aziz Cherif*, Marouen Benna, Ameni Yousfi, Semia Zaraa, Rim Abidi, Chiraz Nasr. Pattern of LRR in Endometrial Cancer and Identification of Predictive Factors. Clin J Obstet Gynecol. 2024: doi: 10.29328/journal.cjog.1001169; 7: 078-083
  • Effect of Azithromycin on Lung Function and Pulmonary Exacerbations in Children with Post-infectious Bronchiolitis Obliterans. A Double-blind, Placebo-controlled Trial
    Castaños Claudio*, Salin Maximiliano Felix, Pereyra Carla Luciana, Aguerre Veronica, Lucero Maria Belen, Bauer Gabriela, Zylbersztajn Brenda, Leviled Leonor and Gonzalez Pena Hebe Castaños Claudio*, Salin Maximiliano Felix, Pereyra Carla Luciana, Aguerre Veronica, Lucero Maria Belen, Bauer Gabriela, Zylbersztajn Brenda, Leviled Leonor, Gonzalez Pena Hebe. Effect of Azithromycin on Lung Function and Pulmonary Exacerbations in Children with Post-infectious Bronchiolitis Obliterans. A Double-blind, Placebo-controlled Trial. J Pulmonol Respir Res. 2024: doi: 10.29328/journal.jprr.1001052; 8: 009-014
  • Pituitary gland metastasis from breast cancer: case report
    Mohamed Almadhoni and Mohamed Ali Baggas* Mohamed Almadhoni,Mohamed Ali Baggas*. Pituitary gland metastasis from breast cancer: case report. Arch Cancer Sci Ther. 2022: doi: 10.29328/journal.acst.1001025; 6: 001-003

Read More

Most Viewed

Read More

Help ?